| Game Date | Arena | Score | Opponent | Location | Outcome | Game Chart |
| Fri 11/09/2012 | Ramstein Air Force Base, Ramstein
| 66 - 62 | 14 (26-9) Michigan St at 41 (20-10) Connecticut | Neutral | L | 0.250 |
| Tue 11/13/2012 | Georgia Dome, Atlanta, GA
| 64 - 67 | 14 (26-9) Michigan St at 6 (31-6) Kansas | Neutral | W | 0.382 |
| Sun 11/18/2012 | Jack Breslin Student Events Center, East Lansing, MI
| 69 - 41 | 162 (17-14) Texas Southern at 14 (26-9) Michigan St | Home | W | 0.997 |
| Tue 11/20/2012 | Jack Breslin Student Events Center, East Lansing, MI
| 74 - 70 | 89 (19-11) Boise St at 14 (26-9) Michigan St | Home | W | 0.806 |
| Fri 11/23/2012 | Jack Breslin Student Events Center, East Lansing, MI
| 70 - 52 | 176 (14-17) Oakland at 14 (26-9) Michigan St | Home | W | 0.983 |
| Sun 11/25/2012 | Jack Breslin Student Events Center, East Lansing, MI
| 63 - 60 | 218 (12-20) LA-Lafayette at 14 (26-9) Michigan St | Home | W | 0.976 |
| Wed 11/28/2012 | BankUnited Center, Coral Gables, FL
| 67 - 59 | 14 (26-9) Michigan St at 7 (29-7) Miami (FL) | Away | L | 0.111 |
| Sat 12/01/2012 | Jack Breslin Student Events Center, East Lansing, MI
| 84 - 39 | 291 (9-21) Nicholls St at 14 (26-9) Michigan St | Home | W | 0.997 |
| Wed 12/05/2012 | Jack Breslin Student Events Center, East Lansing, MI
| 76 - 44 | 278 (16-14) AR-Pine Bluff at 14 (26-9) Michigan St | Home | W | 0.999 |
| Sat 12/08/2012 | Jack Breslin Student Events Center, East Lansing, MI
| 73 - 61 | 217 (14-16) Loyola (IL) at 14 (26-9) Michigan St | Home | W | 0.965 |
| Tue 12/18/2012 | Stroh Center, Bowling Green, OH
| 53 - 64 | 14 (26-9) Michigan St at 215 (11-19) Bowling Green | Away | W | 0.850 |
| Sat 12/22/2012 | Jack Breslin Student Events Center, East Lansing, MI
| 67 - 56 | 108 (16-17) Texas at 14 (26-9) Michigan St | Home | W | 0.863 |
| Mon 12/31/2012 | Williams Arena, Minneapolis, MN
| 76 - 63 | 14 (26-9) Michigan St at 22 (21-13) Minnesota | Away | L | 0.357 |
| Sat 01/05/2013 | Jack Breslin Student Events Center, East Lansing, MI
| 84 - 61 | 78 (16-18) Purdue at 14 (26-9) Michigan St | Home | W | 0.929 |
| Thu 01/10/2013 | Carver-Hawkeye Arena, Iowa City, IA
| 59 - 62 | 14 (26-9) Michigan St at 48 (25-13) Iowa | Away | W | 0.343 |
| Sun 01/13/2013 | Jack Breslin Student Events Center, East Lansing, MI
| 66 - 56 | 79 (15-18) Nebraska at 14 (26-9) Michigan St | Home | W | 0.827 |
| Wed 01/16/2013 | Bryce Jordan Center, University Park, PA
| 72 - 81 | 14 (26-9) Michigan St at 135 (10-21) Penn St | Away | W | 0.825 |
| Sat 01/19/2013 | Jack Breslin Student Events Center, East Lansing, MI
| 59 - 56 | 8 (29-8) Ohio St at 14 (26-9) Michigan St | Home | W | 0.699 |
| Tue 01/22/2013 | Kohl Center, Madison, WI
| 47 - 49 | 14 (26-9) Michigan St at 27 (23-12) Wisconsin | Away | W | 0.526 |
| Sun 01/27/2013 | Assembly Hall, Bloomington, IN
| 75 - 70 | 14 (26-9) Michigan St at 5 (29-7) Indiana | Away | L | 0.255 |
| Thu 01/31/2013 | Jack Breslin Student Events Center, East Lansing, MI
| 80 - 75 | 42 (22-13) Illinois at 14 (26-9) Michigan St | Home | W | 0.664 |
| Wed 02/06/2013 | Jack Breslin Student Events Center, East Lansing, MI
| 61 - 50 | 22 (21-13) Minnesota at 14 (26-9) Michigan St | Home | W | 0.816 |
| Sat 02/09/2013 | Mackey Arena, West Lafayette, IN
| 65 - 78 | 14 (26-9) Michigan St at 78 (16-18) Purdue | Away | W | 0.925 |
| Tue 02/12/2013 | Jack Breslin Student Events Center, East Lansing, MI
| 75 - 52 | 18 (30-8) Michigan at 14 (26-9) Michigan St | Home | W | 0.946 |
| Sat 02/16/2013 | Bob Devaney Sports Center, Lincoln, NE
| 64 - 73 | 14 (26-9) Michigan St at 79 (15-18) Nebraska | Away | W | 0.853 |
| Tue 02/19/2013 | Jack Breslin Student Events Center, East Lansing, MI
| 68 - 72 | 5 (29-7) Indiana at 14 (26-9) Michigan St | Home | L | 0.448 |
| Sun 02/24/2013 | Value City Arena, Columbus, OH
| 68 - 60 | 14 (26-9) Michigan St at 8 (29-8) Ohio St | Away | L | 0.253 |
| Sun 03/03/2013 | Crisler Center, Ann Arbor, MI
| 58 - 57 | 14 (26-9) Michigan St at 18 (30-8) Michigan | Away | L | 0.305 |
| Thu 03/07/2013 | Jack Breslin Student Events Center, East Lansing, MI
| 58 - 43 | 27 (23-12) Wisconsin at 14 (26-9) Michigan St | Home | W | 0.893 |
| Sun 03/10/2013 | Jack Breslin Student Events Center, East Lansing, MI
| 71 - 61 | 104 (13-19) Northwestern at 14 (26-9) Michigan St | Home | W | 0.920 |
| Fri 03/15/2013 | United Center, Chicago, IL
| 59 - 56 | 48 (25-13) Iowa at 14 (26-9) Michigan St | Home | W | 0.383 |
| Sat 03/16/2013 | United Center, Chicago, IL
| 61 - 58 | 14 (26-9) Michigan St at 8 (29-8) Ohio St | Away | L | 0.272 |
| Thu 03/21/2013 | The Palace of Auburn Hills, Auburn Hills, MI
| 65 - 54 | 103 (25-8) Valparaiso at 14 (26-9) Michigan St | Home | W | 0.979 |
| Sat 03/23/2013 | The Palace of Auburn Hills, Auburn Hills, MI
| 70 - 48 | 11 (31-5) Memphis at 14 (26-9) Michigan St | Home | W | 0.893 |
| Fri 03/29/2013 | Lucas Oil Stadium, Indianapolis, IN
| 71 - 61 | 14 (26-9) Michigan St at 2 (30-6) Duke | Away | L | 0.167 |