| Game Date | Arena | Score | Opponent | Location | Outcome | Game Chart |
| Sun 11/11/2012 | USS Midway, San Diego, CA
| 49 - 62 | 4 (30-10) Syracuse at 54 (21-11) San Diego St | Neutral | W | 0.948 |
| Sun 11/18/2012 | Carrier Dome, Syracuse, NY
| 88 - 57 | 182 (19-12) Wagner at 4 (30-10) Syracuse | Home | W | 0.994 |
| Wed 11/21/2012 | Carrier Dome, Syracuse, NY
| 73 - 53 | 128 (16-11) Princeton at 4 (30-10) Syracuse | Home | W | 0.979 |
| Sun 11/25/2012 | Carrier Dome, Syracuse, NY
| 87 - 51 | 261 (11-21) Colgate at 4 (30-10) Syracuse | Home | W | 0.997 |
| Fri 11/30/2012 | Bud Walton Arena, Fayetteville, AR
| 82 - 91 | 4 (30-10) Syracuse at 64 (19-13) Arkansas | Away | W | 0.885 |
| Mon 12/03/2012 | Carrier Dome, Syracuse, NY
| 84 - 48 | 249 (13-18) E Michigan at 4 (30-10) Syracuse | Home | W | 0.994 |
| Thu 12/06/2012 | Carrier Dome, Syracuse, NY
| 84 - 53 | 155 (17-14) Long Beach St at 4 (30-10) Syracuse | Home | W | 0.998 |
| Sat 12/08/2012 | Carrier Dome, Syracuse, NY
| 108 - 56 | 305 (10-21) Monmouth at 4 (30-10) Syracuse | Home | W | 0.997 |
| Sat 12/15/2012 | Carrier Dome, Syracuse, NY
| 85 - 61 | 117 (20-14) Canisius at 4 (30-10) Syracuse | Home | W | 0.950 |
| Mon 12/17/2012 | Carrier Dome, Syracuse, NY
| 72 - 68 | 93 (18-13) Detroit at 4 (30-10) Syracuse | Home | W | 0.981 |
| Sat 12/22/2012 | Madison Square Garden, New York, NY
| 83 - 79 | 4 (30-10) Syracuse at 36 (24-10) Temple | Neutral | L | 0.315 |
| Sat 12/29/2012 | Carrier Dome, Syracuse, NY
| 57 - 36 | 290 (9-23) Alcorn St at 4 (30-10) Syracuse | Home | W | 0.993 |
| Mon 12/31/2012 | Carrier Dome, Syracuse, NY
| 96 - 62 | 273 (13-17) Cent Conn St at 4 (30-10) Syracuse | Home | W | 0.993 |
| Wed 01/02/2013 | Carrier Dome, Syracuse, NY
| 78 - 53 | 70 (15-16) Rutgers at 4 (30-10) Syracuse | Home | W | 0.961 |
| Sun 01/06/2013 | USF Sun Dome, Tampa, FL
| 44 - 55 | 4 (30-10) Syracuse at 85 (12-19) South Florida | Away | W | 0.806 |
| Wed 01/09/2013 | Dunkin Donuts Center, Providence, RI
| 66 - 72 | 4 (30-10) Syracuse at 66 (19-15) Providence | Away | W | 0.696 |
| Sat 01/12/2013 | Carrier Dome, Syracuse, NY
| 72 - 61 | 49 (19-14) Villanova at 4 (30-10) Syracuse | Home | W | 0.765 |
| Sat 01/19/2013 | KFC Yum! Center, Louisville, KY
| 68 - 70 | 4 (30-10) Syracuse at 1 (35-5) Louisville | Away | W | 0.362 |
| Mon 01/21/2013 | Carrier Dome, Syracuse, NY
| 57 - 55 | 26 (22-12) Cincinnati at 4 (30-10) Syracuse | Home | W | 0.524 |
| Sat 01/26/2013 | Wells Fargo Arena, Des Moines, IA
| 75 - 71 | 4 (30-10) Syracuse at 49 (19-14) Villanova | Neutral | L | 0.471 |
| Sat 02/02/2013 | Petersen Events Center, Pittsburgh, PA
| 65 - 55 | 4 (30-10) Syracuse at 45 (24-9) Pittsburgh | Away | L | 0.236 |
| Mon 02/04/2013 | Carrier Dome, Syracuse, NY
| 63 - 47 | 33 (25-10) Notre Dame at 4 (30-10) Syracuse | Home | W | 0.866 |
| Sun 02/10/2013 | Carrier Dome, Syracuse, NY
| 77 - 58 | 57 (17-16) St. Johns at 4 (30-10) Syracuse | Home | W | 0.972 |
| Wed 02/13/2013 | XL Center, Hartford, CT
| 66 - 58 | 4 (30-10) Syracuse at 41 (20-10) Connecticut | Away | L | 0.267 |
| Sat 02/16/2013 | Prudential Center, Newark, NJ
| 65 - 76 | 4 (30-10) Syracuse at 101 (15-18) Seton Hall | Away | W | 0.826 |
| Wed 02/20/2013 | Carrier Dome, Syracuse, NY
| 84 - 59 | 66 (19-15) Providence at 4 (30-10) Syracuse | Home | W | 0.977 |
| Sat 02/23/2013 | Carrier Dome, Syracuse, NY
| 46 - 57 | 15 (25-7) Georgetown at 4 (30-10) Syracuse | Home | L | 0.349 |
| Mon 02/25/2013 | BMO Harris Bradley Center, Milwaukee, WI
| 74 - 71 | 4 (30-10) Syracuse at 12 (26-9) Marquette | Away | L | 0.477 |
| Sat 03/02/2013 | Carrier Dome, Syracuse, NY
| 53 - 58 | 1 (35-5) Louisville at 4 (30-10) Syracuse | Home | L | 0.475 |
| Wed 03/06/2013 | Carrier Dome, Syracuse, NY
| 78 - 57 | 143 (11-21) DePaul at 4 (30-10) Syracuse | Home | W | 0.938 |
| Sat 03/09/2013 | Verizon Center, Washington, DC
| 61 - 39 | 4 (30-10) Syracuse at 15 (25-7) Georgetown | Away | L | 0.112 |
| Wed 03/13/2013 | Madison Square Garden, New York, NY
| 75 - 63 | 101 (15-18) Seton Hall at 4 (30-10) Syracuse | Home | W | 0.854 |
| Thu 03/14/2013 | Madison Square Garden, New York, NY
| 59 - 62 | 4 (30-10) Syracuse at 45 (24-9) Pittsburgh | Away | W | 0.740 |
| Fri 03/15/2013 | Madison Square Garden, New York, NY
| 55 - 58 | 4 (30-10) Syracuse at 15 (25-7) Georgetown | Away | W | 0.654 |
| Sat 03/16/2013 | Madison Square Garden, New York, NY
| 78 - 61 | 4 (30-10) Syracuse at 1 (35-5) Louisville | Away | L | 0.401 |
| Thu 03/21/2013 | HP Pavilion at San Jose, San Jose, CA
| 81 - 34 | 116 (23-7) Montana at 4 (30-10) Syracuse | Home | W | 0.992 |
| Sat 03/23/2013 | HP Pavilion at San Jose, San Jose, CA
| 66 - 60 | 39 (21-12) California at 4 (30-10) Syracuse | Home | W | 0.912 |
| Thu 03/28/2013 | Verizon Center, Washington, DC
| 50 - 61 | 4 (30-10) Syracuse at 5 (29-7) Indiana | Away | W | 0.845 |
| Sat 03/30/2013 | Verizon Center, Washington, DC
| 39 - 55 | 4 (30-10) Syracuse at 12 (26-9) Marquette | Away | W | 0.782 |
| Sat 04/06/2013 | Georgia Dome, Atlanta, GA
| 61 - 56 | 4 (30-10) Syracuse at 18 (30-8) Michigan | Away | L | 0.195 |