| Game Date | Arena | Score | Opponent | Location | Outcome | Game Chart |
| Fri 11/09/2012 | Petersen Events Center, Pittsburgh, PA
| 80 - 48 | 195 (17-14) Mount St. Marys at 45 (24-9) Pittsburgh | Home | W | 0.996 |
| Mon 11/12/2012 | Petersen Events Center, Pittsburgh, PA
| 86 - 51 | 226 (7-24) Fordham at 45 (24-9) Pittsburgh | Home | W | 0.996 |
| Tue 11/13/2012 | Petersen Events Center, Pittsburgh, PA
| 78 - 53 | 150 (20-10) Lehigh at 45 (24-9) Pittsburgh | Home | W | 0.943 |
| Sat 11/17/2012 | Petersen Events Center, Pittsburgh, PA
| 72 - 62 | 176 (14-17) Oakland at 45 (24-9) Pittsburgh | Home | W | 0.595 |
| Wed 11/21/2012 | Madison Square Garden, New York, NY
| 67 - 62 | 45 (24-9) Pittsburgh at 18 (30-8) Michigan | Neutral | L | 0.397 |
| Fri 11/23/2012 | Madison Square Garden, New York, NY
| 85 - 59 | 166 (19-14) Delaware at 45 (24-9) Pittsburgh | Neutral | W | 0.999 |
| Tue 11/27/2012 | Petersen Events Center, Pittsburgh, PA
| 70 - 46 | 313 (6-23) Howard at 45 (24-9) Pittsburgh | Home | W | 0.992 |
| Sat 12/01/2012 | Petersen Events Center, Pittsburgh, PA
| 74 - 61 | 93 (18-13) Detroit at 45 (24-9) Pittsburgh | Home | W | 0.785 |
| Wed 12/05/2012 | CONSOL Energy Center, Pittsburgh, PA
| 66 - 45 | 172 (8-22) Duquesne at 45 (24-9) Pittsburgh | Neutral | W | 0.992 |
| Sat 12/08/2012 | Petersen Events Center, Pittsburgh, PA
| 89 - 47 | 240 (12-19) North Florida at 45 (24-9) Pittsburgh | Home | W | 0.992 |
| Sat 12/15/2012 | Petersen Events Center, Pittsburgh, PA
| 89 - 40 | 296 (12-20) Bethune-Cook. at 45 (24-9) Pittsburgh | Home | W | 0.996 |
| Wed 12/19/2012 | Petersen Events Center, Pittsburgh, PA
| 71 - 43 | 322 (13-18) Delaware St at 45 (24-9) Pittsburgh | Home | W | 0.990 |
| Sun 12/23/2012 | Petersen Events Center, Pittsburgh, PA
| 59 - 43 | 333 (3-27) Kennesaw St at 45 (24-9) Pittsburgh | Home | W | 0.992 |
| Mon 12/31/2012 | Petersen Events Center, Pittsburgh, PA
| 61 - 70 | 26 (22-12) Cincinnati at 45 (24-9) Pittsburgh | Home | L | 0.432 |
| Sat 01/05/2013 | Louis Brown Athletic Center, Piscataway, NJ
| 67 - 62 | 45 (24-9) Pittsburgh at 70 (15-16) Rutgers | Away | L | 0.280 |
| Tue 01/08/2013 | Verizon Center, Washington, DC
| 45 - 73 | 45 (24-9) Pittsburgh at 15 (25-7) Georgetown | Away | W | 0.862 |
| Sat 01/12/2013 | Petersen Events Center, Pittsburgh, PA
| 67 - 74 | 12 (26-9) Marquette at 45 (24-9) Pittsburgh | Home | L | 0.408 |
| Wed 01/16/2013 | The Pavilion, Villanova, PA
| 43 - 58 | 45 (24-9) Pittsburgh at 49 (19-14) Villanova | Away | W | 0.574 |
| Sat 01/19/2013 | Petersen Events Center, Pittsburgh, PA
| 69 - 61 | 41 (20-10) Connecticut at 45 (24-9) Pittsburgh | Home | W | 0.857 |
| Tue 01/22/2013 | Dunkin Donuts Center, Providence, RI
| 64 - 68 | 45 (24-9) Pittsburgh at 66 (19-15) Providence | Away | W | 0.846 |
| Sat 01/26/2013 | Petersen Events Center, Pittsburgh, PA
| 93 - 55 | 143 (11-21) DePaul at 45 (24-9) Pittsburgh | Home | W | 0.990 |
| Mon 01/28/2013 | KFC Yum! Center, Louisville, KY
| 64 - 61 | 45 (24-9) Pittsburgh at 1 (35-5) Louisville | Away | L | 0.132 |
| Sat 02/02/2013 | Petersen Events Center, Pittsburgh, PA
| 65 - 55 | 4 (30-10) Syracuse at 45 (24-9) Pittsburgh | Home | W | 0.763 |
| Mon 02/04/2013 | Petersen Events Center, Pittsburgh, PA
| 56 - 46 | 101 (15-18) Seton Hall at 45 (24-9) Pittsburgh | Home | W | 0.861 |
| Sat 02/09/2013 | Fifth Third Arena, Cincinnati, OH
| 52 - 62 | 45 (24-9) Pittsburgh at 26 (22-12) Cincinnati | Away | W | 0.418 |
| Sat 02/16/2013 | BMO Harris Bradley Center, Milwaukee, WI
| 79 - 69 | 45 (24-9) Pittsburgh at 12 (26-9) Marquette | Away | L | 0.082 |
| Mon 02/18/2013 | Petersen Events Center, Pittsburgh, PA
| 42 - 51 | 33 (25-10) Notre Dame at 45 (24-9) Pittsburgh | Home | L | 0.476 |
| Sun 02/24/2013 | Madison Square Garden, New York, NY
| 47 - 63 | 45 (24-9) Pittsburgh at 57 (17-16) St. Johns | Away | W | 0.835 |
| Wed 02/27/2013 | Petersen Events Center, Pittsburgh, PA
| 64 - 44 | 85 (12-19) South Florida at 45 (24-9) Pittsburgh | Home | W | 0.914 |
| Sun 03/03/2013 | Petersen Events Center, Pittsburgh, PA
| 73 - 64 | 49 (19-14) Villanova at 45 (24-9) Pittsburgh | Home | W | 0.412 |
| Sat 03/09/2013 | Allstate Arena, Rosemont, IL
| 66 - 81 | 45 (24-9) Pittsburgh at 143 (11-21) DePaul | Away | W | 0.904 |
| Thu 03/14/2013 | Madison Square Garden, New York, NY
| 59 - 62 | 4 (30-10) Syracuse at 45 (24-9) Pittsburgh | Home | L | 0.259 |
| Thu 03/21/2013 | EnergySolutions Arena, Salt Lake City, UT
| 55 - 73 | 28 (30-9) Wichita St at 45 (24-9) Pittsburgh | Home | L | 0.275 |