| Game Date | Arena | Score | Opponent | Location | Outcome | Game Chart |
| Sun 11/11/2012 | The Pavilion, Villanova, PA
| 80 - 68 | 153 (12-19) Marshall at 49 (19-14) Villanova | Home | W | 0.975 |
| Thu 11/15/2012 | Madison Square Garden, New York, NY
| 81 - 89 | 49 (19-14) Villanova at 78 (16-18) Purdue | Neutral | W | 0.536 |
| Fri 11/16/2012 | Madison Square Garden, New York, NY
| 77 - 55 | 49 (19-14) Villanova at 60 (22-13) Alabama | Neutral | L | 0.310 |
| Tue 11/20/2012 | The Pavilion, Villanova, PA
| 57 - 75 | 250 (10-16) Columbia at 49 (19-14) Villanova | Home | L | 0.616 |
| Sun 11/25/2012 | Tom Gola Arena, Philadelphia, PA
| 77 - 74 | 49 (19-14) Villanova at 59 (24-10) La Salle | Away | L | 0.708 |
| Sat 12/01/2012 | Memorial Gym, Nashville, TN
| 52 - 62 | 49 (19-14) Villanova at 71 (16-17) Vanderbilt | Away | W | 0.798 |
| Wed 12/05/2012 | The Pavilion, Villanova, PA
| 61 - 76 | 36 (24-10) Temple at 49 (19-14) Villanova | Home | L | 0.305 |
| Sat 12/08/2012 | Palestra, Philadelphia, PA
| 55 - 68 | 49 (19-14) Villanova at 272 (9-22) Pennsylvania | Away | W | 0.930 |
| Tue 12/11/2012 | The Pavilion, Villanova, PA
| 65 - 61 | 91 (18-14) Saint Josephs at 49 (19-14) Villanova | Home | W | 0.688 |
| Sun 12/16/2012 | The Pavilion, Villanova, PA
| 75 - 65 | 166 (19-14) Delaware at 49 (19-14) Villanova | Home | W | 0.982 |
| Sat 12/22/2012 | Multipurpose Activity Center, West Long Branch, NJ
| 56 - 83 | 49 (19-14) Villanova at 305 (10-21) Monmouth | Away | W | 0.977 |
| Fri 12/28/2012 | The Pavilion, Villanova, PA
| 70 - 60 | 341 (12-13) N.J.I.T. at 49 (19-14) Villanova | Home | W | 0.951 |
| Wed 01/02/2013 | The Pavilion, Villanova, PA
| 98 - 86 | 57 (17-16) St. Johns at 49 (19-14) Villanova | Home | W | 0.826 |
| Wed 01/09/2013 | USF Sun Dome, Tampa, FL
| 53 - 61 | 49 (19-14) Villanova at 85 (12-19) South Florida | Away | W | 0.755 |
| Sat 01/12/2013 | Carrier Dome, Syracuse, NY
| 72 - 61 | 49 (19-14) Villanova at 4 (30-10) Syracuse | Away | L | 0.234 |
| Wed 01/16/2013 | The Pavilion, Villanova, PA
| 43 - 58 | 45 (24-9) Pittsburgh at 49 (19-14) Villanova | Home | L | 0.425 |
| Sat 01/19/2013 | Dunkin Donuts Center, Providence, RI
| 69 - 66 | 49 (19-14) Villanova at 66 (19-15) Providence | Away | L | 0.626 |
| Tue 01/22/2013 | The Pavilion, Villanova, PA
| 73 - 64 | 1 (35-5) Louisville at 49 (19-14) Villanova | Home | W | 0.607 |
| Sat 01/26/2013 | Wells Fargo Arena, Des Moines, IA
| 75 - 71 | 4 (30-10) Syracuse at 49 (19-14) Villanova | Neutral | W | 0.528 |
| Wed 01/30/2013 | Purcell Pavilion at the Joyce Center, South Bend, IN
| 65 - 60 | 49 (19-14) Villanova at 33 (25-10) Notre Dame | Away | L | 0.294 |
| Sun 02/03/2013 | The Pavilion, Villanova, PA
| 52 - 55 | 66 (19-15) Providence at 49 (19-14) Villanova | Home | L | 0.616 |
| Tue 02/05/2013 | Allstate Arena, Rosemont, IL
| 71 - 94 | 49 (19-14) Villanova at 143 (11-21) DePaul | Away | W | 0.865 |
| Sat 02/09/2013 | The Pavilion, Villanova, PA
| 68 - 40 | 85 (12-19) South Florida at 49 (19-14) Villanova | Home | W | 0.986 |
| Tue 02/12/2013 | Fifth Third Arena, Cincinnati, OH
| 68 - 50 | 49 (19-14) Villanova at 26 (22-12) Cincinnati | Away | L | 0.128 |
| Sat 02/16/2013 | XL Center, Hartford, CT
| 61 - 70 | 49 (19-14) Villanova at 41 (20-10) Connecticut | Away | W | 0.543 |
| Mon 02/18/2013 | The Pavilion, Villanova, PA
| 71 - 63 | 70 (15-16) Rutgers at 49 (19-14) Villanova | Home | W | 0.752 |
| Sat 02/23/2013 | The Pavilion, Villanova, PA
| 60 - 56 | 12 (26-9) Marquette at 49 (19-14) Villanova | Home | W | 0.743 |
| Mon 02/25/2013 | Prudential Center, Newark, NJ
| 66 - 65 | 49 (19-14) Villanova at 101 (15-18) Seton Hall | Away | L | 0.685 |
| Sun 03/03/2013 | Petersen Events Center, Pittsburgh, PA
| 73 - 64 | 49 (19-14) Villanova at 45 (24-9) Pittsburgh | Away | L | 0.587 |
| Wed 03/06/2013 | Wells Fargo Center, Philadelphia, PA
| 67 - 57 | 15 (25-7) Georgetown at 49 (19-14) Villanova | Home | W | 0.772 |
| Wed 03/13/2013 | Madison Square Garden, New York, NY
| 66 - 53 | 57 (17-16) St. Johns at 49 (19-14) Villanova | Home | W | 0.918 |
| Thu 03/14/2013 | Madison Square Garden, New York, NY
| 74 - 55 | 49 (19-14) Villanova at 1 (35-5) Louisville | Away | L | 0.080 |
| Fri 03/22/2013 | Sprint Center, Kansas City, MO
| 78 - 71 | 49 (19-14) Villanova at 21 (24-11) North Carolina | Away | L | 0.180 |