| Game Date | Arena | Score | Opponent | Location | Outcome | Game Chart |
| Sat 11/10/2012 | Tom Gola Arena, Philadelphia, PA
| 73 - 66 | 166 (19-14) Delaware at 59 (24-10) La Salle | Home | W | 0.864 |
| Sun 11/18/2012 | Tom Gola Arena, Philadelphia, PA
| 74 - 81 | 273 (13-17) Cent Conn St at 59 (24-10) La Salle | Home | L | 0.611 |
| Tue 11/20/2012 | Chase Family Arena, Hartford, CT
| 51 - 64 | 59 (24-10) La Salle at 228 (17-14) Hartford | Away | W | 0.947 |
| Sun 11/25/2012 | Tom Gola Arena, Philadelphia, PA
| 77 - 74 | 49 (19-14) Villanova at 59 (24-10) La Salle | Home | W | 0.291 |
| Thu 11/29/2012 | Alumni Gymnasium, Lawrenceville, NJ
| 52 - 63 | 59 (24-10) La Salle at 164 (19-15) Rider | Away | W | 0.929 |
| Wed 12/05/2012 | Palestra, Philadelphia, PA
| 82 - 57 | 135 (10-21) Penn St at 59 (24-10) La Salle | Neutral | W | 0.870 |
| Sat 12/08/2012 | Matthews Arena, Boston, MA
| 64 - 66 | 59 (24-10) La Salle at 160 (20-13) Northeastern | Away | W | 0.702 |
| Sat 12/15/2012 | Sojka Pavilion, Lewisburg, PA
| 74 - 66 | 59 (24-10) La Salle at 81 (27-6) Bucknell | Away | L | 0.121 |
| Thu 12/20/2012 | Tom Gola Arena, Philadelphia, PA
| 88 - 74 | 105 (20-14) Iona at 59 (24-10) La Salle | Home | W | 0.765 |
| Sat 12/22/2012 | Tom Gola Arena, Philadelphia, PA
| 100 - 71 | 269 (9-20) Sacred Heart at 59 (24-10) La Salle | Home | W | 0.997 |
| Sat 12/29/2012 | Times Union Center, Albany, NY
| 52 - 80 | 59 (24-10) La Salle at 307 (8-24) Siena | Away | W | 0.941 |
| Wed 01/02/2013 | BankUnited Center, Coral Gables, FL
| 76 - 59 | 59 (24-10) La Salle at 7 (29-7) Miami (FL) | Away | L | 0.143 |
| Sat 01/05/2013 | Tom Gola Arena, Philadelphia, PA
| 74 - 57 | 272 (9-22) Pennsylvania at 59 (24-10) La Salle | Home | W | 0.974 |
| Wed 01/09/2013 | Dale F. Halton Arena, Charlotte, NC
| 74 - 65 | 59 (24-10) La Salle at 107 (20-12) Charlotte | Away | L | 0.091 |
| Sat 01/12/2013 | Tom Gola Arena, Philadelphia, PA
| 71 - 59 | 63 (19-15) Richmond at 59 (24-10) La Salle | Home | W | 0.953 |
| Wed 01/16/2013 | Tom Gola Arena, Philadelphia, PA
| 72 - 70 | 72 (17-14) Dayton at 59 (24-10) La Salle | Home | W | 0.594 |
| Sat 01/19/2013 | Cintas Center, Cincinnati, OH
| 70 - 63 | 59 (24-10) La Salle at 61 (17-14) Xavier | Away | L | 0.179 |
| Wed 01/23/2013 | Tom Gola Arena, Philadelphia, PA
| 54 - 53 | 24 (26-9) Butler at 59 (24-10) La Salle | Home | W | 0.375 |
| Sat 01/26/2013 | Stuart Siegel Center, Richmond, VA
| 61 - 69 | 59 (24-10) La Salle at 13 (27-9) VCU | Away | W | 0.418 |
| Wed 01/30/2013 | Tom Gola Arena, Philadelphia, PA
| 60 - 61 | 68 (21-12) Massachusetts at 59 (24-10) La Salle | Home | L | 0.471 |
| Sat 02/02/2013 | Charles E. Smith Center, Washington, DC
| 71 - 80 | 59 (24-10) La Salle at 124 (13-17) G. Washington | Away | W | 0.855 |
| Sat 02/09/2013 | Tom Gola Arena, Philadelphia, PA
| 89 - 53 | 226 (7-24) Fordham at 59 (24-10) La Salle | Home | W | 0.996 |
| Wed 02/13/2013 | Reilly Center, St. Bonaventure, NY
| 66 - 69 | 59 (24-10) La Salle at 110 (14-15) St. Bonaventure | Away | W | 0.525 |
| Sat 02/16/2013 | Palestra, Philadelphia, PA
| 76 - 64 | 91 (18-14) Saint Josephs at 59 (24-10) La Salle | Neutral | W | 0.833 |
| Thu 02/21/2013 | Liacouras Center, Philadelphia, PA
| 82 - 74 | 59 (24-10) La Salle at 36 (24-10) Temple | Away | L | 0.041 |
| Sun 02/24/2013 | Thomas M. Ryan Center, Kingston, RI
| 65 - 72 | 59 (24-10) La Salle at 120 (8-21) Rhode Island | Away | W | 0.619 |
| Sat 03/02/2013 | Tom Gola Arena, Philadelphia, PA
| 97 - 64 | 172 (8-22) Duquesne at 59 (24-10) La Salle | Home | W | 0.996 |
| Wed 03/06/2013 | Tom Gola Arena, Philadelphia, PA
| 84 - 70 | 124 (13-17) G. Washington at 59 (24-10) La Salle | Home | W | 0.928 |
| Sat 03/09/2013 | Chaifetz Arena, St. Louis, MO
| 78 - 54 | 59 (24-10) La Salle at 16 (28-7) Saint Louis | Away | L | 0.081 |
| Fri 03/15/2013 | Barclays Center, Brooklyn, NY
| 58 - 69 | 24 (26-9) Butler at 59 (24-10) La Salle | Home | L | 0.156 |
| Wed 03/20/2013 | University of Dayton Arena, Dayton, OH
| 71 - 80 | 59 (24-10) La Salle at 89 (19-11) Boise St | Away | W | 0.800 |
| Fri 03/22/2013 | Sprint Center, Kansas City, MO
| 61 - 63 | 59 (24-10) La Salle at 31 (26-8) Kansas St | Away | W | 0.519 |
| Sun 03/24/2013 | Sprint Center, Kansas City, MO
| 74 - 76 | 59 (24-10) La Salle at 86 (27-9) Ole Miss | Away | W | 0.407 |
| Thu 03/28/2013 | Staples Center, Los Angeles, CA
| 72 - 58 | 59 (24-10) La Salle at 28 (30-9) Wichita St | Away | L | 0.019 |