| Game Date | Arena | Score | Opponent | Location | Outcome | Game Chart |
| Fri 11/09/2012 | Mackey Arena, West Lafayette, IN
| 65 - 70 | 81 (27-6) Bucknell at 78 (16-18) Purdue | Home | L | 0.564 |
| Sun 11/11/2012 | Mackey Arena, West Lafayette, IN
| 83 - 54 | 289 (6-25) Hofstra at 78 (16-18) Purdue | Home | W | 0.994 |
| Thu 11/15/2012 | Madison Square Garden, New York, NY
| 81 - 89 | 49 (19-14) Villanova at 78 (16-18) Purdue | Neutral | L | 0.463 |
| Fri 11/16/2012 | Madison Square Garden, New York, NY
| 66 - 58 | 78 (16-18) Purdue at 90 (14-18) Oregon St | Neutral | L | 0.147 |
| Wed 11/21/2012 | Mackey Arena, West Lafayette, IN
| 66 - 40 | 285 (9-20) UNC-Wilmington at 78 (16-18) Purdue | Home | W | 0.949 |
| Wed 11/28/2012 | Littlejohn Coliseum, Clemson, SC
| 61 - 73 | 78 (16-18) Purdue at 125 (13-18) Clemson | Away | W | 0.878 |
| Sat 12/01/2012 | Mackey Arena, West Lafayette, IN
| 57 - 63 | 61 (17-14) Xavier at 78 (16-18) Purdue | Home | L | 0.511 |
| Tue 12/04/2012 | Mackey Arena, West Lafayette, IN
| 72 - 39 | 336 (3-28) Lamar at 78 (16-18) Purdue | Home | W | 0.993 |
| Sat 12/08/2012 | Convocation Center, Ypsilanti, MI
| 47 - 44 | 78 (16-18) Purdue at 249 (13-18) E Michigan | Away | L | 0.428 |
| Sat 12/15/2012 | Bankers Life Fieldhouse, Indianapolis, IN
| 81 - 68 | 78 (16-18) Purdue at 33 (25-10) Notre Dame | Neutral | L | 0.032 |
| Tue 12/18/2012 | Mackey Arena, West Lafayette, IN
| 66 - 56 | 258 (15-15) Ball St at 78 (16-18) Purdue | Home | W | 0.901 |
| Sat 12/29/2012 | Mackey Arena, West Lafayette, IN
| 73 - 66 | 252 (12-17) William & Mary at 78 (16-18) Purdue | Home | W | 0.876 |
| Wed 01/02/2013 | Mackey Arena, West Lafayette, IN
| 68 - 61 | 42 (22-13) Illinois at 78 (16-18) Purdue | Home | W | 0.487 |
| Sat 01/05/2013 | Jack Breslin Student Events Center, East Lansing, MI
| 84 - 61 | 78 (16-18) Purdue at 14 (26-9) Michigan St | Away | L | 0.070 |
| Tue 01/08/2013 | Mackey Arena, West Lafayette, IN
| 64 - 74 | 8 (29-8) Ohio St at 78 (16-18) Purdue | Home | L | 0.095 |
| Sun 01/13/2013 | Mackey Arena, West Lafayette, IN
| 60 - 42 | 135 (10-21) Penn St at 78 (16-18) Purdue | Home | W | 0.878 |
| Wed 01/16/2013 | Bob Devaney Sports Center, Lincoln, NE
| 56 - 65 | 78 (16-18) Purdue at 79 (15-18) Nebraska | Away | W | 0.794 |
| Sat 01/19/2013 | Mackey Arena, West Lafayette, IN
| 79 - 52 | 95 (13-19) West Virginia at 78 (16-18) Purdue | Home | W | 0.932 |
| Thu 01/24/2013 | Crisler Center, Ann Arbor, MI
| 68 - 53 | 78 (16-18) Purdue at 18 (30-8) Michigan | Away | L | 0.109 |
| Sun 01/27/2013 | Mackey Arena, West Lafayette, IN
| 65 - 62 | 48 (25-13) Iowa at 78 (16-18) Purdue | Home | W | 0.600 |
| Wed 01/30/2013 | Mackey Arena, West Lafayette, IN
| 60 - 97 | 5 (29-7) Indiana at 78 (16-18) Purdue | Home | L | 0.040 |
| Sat 02/02/2013 | Welsh-Ryan Arena, Evanston, IL
| 75 - 60 | 78 (16-18) Purdue at 104 (13-19) Northwestern | Away | L | 0.057 |
| Tue 02/05/2013 | Bryce Jordan Center, University Park, PA
| 49 - 58 | 78 (16-18) Purdue at 135 (10-21) Penn St | Away | W | 0.589 |
| Sat 02/09/2013 | Mackey Arena, West Lafayette, IN
| 65 - 78 | 14 (26-9) Michigan St at 78 (16-18) Purdue | Home | L | 0.074 |
| Wed 02/13/2013 | Assembly Hall, Champaign, IL
| 79 - 59 | 78 (16-18) Purdue at 42 (22-13) Illinois | Away | L | 0.023 |
| Sat 02/16/2013 | Assembly Hall, Bloomington, IN
| 83 - 55 | 78 (16-18) Purdue at 5 (29-7) Indiana | Away | L | 0.013 |
| Sun 02/24/2013 | Mackey Arena, West Lafayette, IN
| 74 - 43 | 104 (13-19) Northwestern at 78 (16-18) Purdue | Home | W | 0.975 |
| Wed 02/27/2013 | Carver-Hawkeye Arena, Iowa City, IA
| 58 - 48 | 78 (16-18) Purdue at 48 (25-13) Iowa | Away | L | 0.048 |
| Sun 03/03/2013 | Kohl Center, Madison, WI
| 56 - 69 | 78 (16-18) Purdue at 27 (23-12) Wisconsin | Away | W | 0.438 |
| Wed 03/06/2013 | Mackey Arena, West Lafayette, IN
| 75 - 80 | 18 (30-8) Michigan at 78 (16-18) Purdue | Home | L | 0.432 |
| Sat 03/09/2013 | Mackey Arena, West Lafayette, IN
| 89 - 73 | 22 (21-13) Minnesota at 78 (16-18) Purdue | Home | W | 0.889 |
| Thu 03/14/2013 | United Center, Chicago, IL
| 55 - 57 | 79 (15-18) Nebraska at 78 (16-18) Purdue | Home | L | 0.339 |
| Wed 03/20/2013 | Mackey Arena, West Lafayette, IN
| 81 - 67 | 239 (20-9) W Illinois at 78 (16-18) Purdue | Home | W | 0.930 |
| Mon 03/25/2013 | Mackey Arena, West Lafayette, IN
| 83 - 86 | 69 (24-12) Santa Clara at 78 (16-18) Purdue | Home | L | 0.371 |