| Game Date | Arena | Score | Opponent | Location | Outcome | Game Chart |
| Sat 11/10/2012 | Reed Green Coliseum, Hattiesburg, MS
| 67 - 64 | 154 (19-16) W Kentucky at 56 (25-10) Southern Miss | Home | W | 0.914 |
| Thu 11/15/2012 | Stegeman Coliseum, Athens, GA
| 60 - 62 | 56 (25-10) Southern Miss at 73 (15-17) Georgia | Away | W | 0.623 |
| Mon 11/19/2012 | Johnson Coliseum, Huntsville, TX
| 49 - 61 | 56 (25-10) Southern Miss at 257 (14-17) Sam Houston St | Away | W | 0.899 |
| Tue 11/20/2012 | Johnson Coliseum, Huntsville, TX
| 69 - 65 | 169 (19-16) UC Irvine at 56 (25-10) Southern Miss | Neutral | W | 0.606 |
| Wed 11/21/2012 |
| 56 - 74 | 56 (25-10) Southern Miss at 247 (12-21) Liberty | Neutral | W | 0.921 |
| Tue 11/27/2012 | Reed Green Coliseum, Hattiesburg, MS
| 61 - 50 | 75 (22-10) Denver at 56 (25-10) Southern Miss | Home | W | 0.941 |
| Sat 12/01/2012 | Pan American Center, Las Cruces, NM
| 68 - 60 | 56 (25-10) Southern Miss at 80 (23-11) New Mexico St | Away | L | 0.088 |
| Tue 12/04/2012 | McKale Center, Tucson, AZ
| 63 - 55 | 56 (25-10) Southern Miss at 17 (27-8) Arizona | Away | L | 0.216 |
| Sat 12/08/2012 | Thomas Assembly Center, Ruston, LA
| 65 - 55 | 56 (25-10) Southern Miss at 133 (26-7) Louisiana Tech | Away | L | 0.197 |
| Sat 12/15/2012 | Reed Green Coliseum, Hattiesburg, MS
| 93 - 45 | 347 (0-28) Grambling St at 56 (25-10) Southern Miss | Home | W | 0.996 |
| Tue 12/18/2012 | GSU Sports Arena, Atlanta, GA
| 67 - 69 | 56 (25-10) Southern Miss at 192 (14-16) Georgia St | Away | W | 0.441 |
| Sat 12/22/2012 | Intrust Bank Arena, Wichita, KS
| 59 - 51 | 56 (25-10) Southern Miss at 28 (30-9) Wichita St | Neutral | L | 0.382 |
| Fri 12/28/2012 | Ellis T Johnson Arena, Morehead, KY
| 58 - 94 | 56 (25-10) Southern Miss at 188 (13-18) Morehead St | Away | W | 0.981 |
| Wed 01/09/2013 | Tudor Fieldhouse, Houston, TX
| 52 - 75 | 56 (25-10) Southern Miss at 263 (4-24) Rice | Away | W | 0.951 |
| Sat 01/12/2013 | Reed Green Coliseum, Hattiesburg, MS
| 73 - 54 | 211 (19-13) Houston at 56 (25-10) Southern Miss | Home | W | 0.962 |
| Wed 01/16/2013 | Moody Coliseum, Dallas, TX
| 70 - 74 | 56 (25-10) Southern Miss at 183 (12-14) S Methodist | Away | W | 0.576 |
| Sat 01/19/2013 | Reed Green Coliseum, Hattiesburg, MS
| 74 - 59 | 144 (13-17) UAB at 56 (25-10) Southern Miss | Home | W | 0.980 |
| Wed 01/23/2013 | Reed Green Coliseum, Hattiesburg, MS
| 102 - 46 | 153 (12-19) Marshall at 56 (25-10) Southern Miss | Home | W | 0.997 |
| Sat 01/26/2013 | Donald Reynolds Center, Tulsa, OK
| 59 - 62 | 56 (25-10) Southern Miss at 156 (16-15) Tulsa | Away | W | 0.750 |
| Sat 02/02/2013 | Bartow Arena, Birmingham, AL
| 75 - 79 | 56 (25-10) Southern Miss at 144 (13-17) UAB | Away | W | 0.729 |
| Wed 02/06/2013 | UCF Arena, Orlando, FL
| 60 - 58 | 56 (25-10) Southern Miss at 84 (18-11) UCF | Away | L | 0.489 |
| Sat 02/09/2013 | Reed Green Coliseum, Hattiesburg, MS
| 76 - 89 | 11 (31-5) Memphis at 56 (25-10) Southern Miss | Home | L | 0.103 |
| Wed 02/13/2013 | Reed Green Coliseum, Hattiesburg, MS
| 71 - 60 | 170 (18-15) Tulane at 56 (25-10) Southern Miss | Home | W | 0.870 |
| Sat 02/16/2013 | Williams Arena at Minges Coliseum, Greenville, NC
| 82 - 86 | 56 (25-10) Southern Miss at 118 (19-12) East Carolina | Away | W | 0.188 |
| Wed 02/20/2013 | Reed Green Coliseum, Hattiesburg, MS
| 45 - 39 | 58 (18-14) UTEP at 56 (25-10) Southern Miss | Home | W | 0.629 |
| Sat 02/23/2013 | FedExForum, Memphis, TN
| 89 - 73 | 56 (25-10) Southern Miss at 11 (31-5) Memphis | Away | L | 0.040 |
| Sat 03/02/2013 | Reed Green Coliseum, Hattiesburg, MS
| 88 - 69 | 118 (19-12) East Carolina at 56 (25-10) Southern Miss | Home | W | 0.855 |
| Tue 03/05/2013 | Henderson Center, Huntington, WV
| 88 - 84 | 56 (25-10) Southern Miss at 153 (12-19) Marshall | Away | L | 0.459 |
| Sat 03/09/2013 | Reed Green Coliseum, Hattiesburg, MS
| 70 - 62 | 84 (18-11) UCF at 56 (25-10) Southern Miss | Home | W | 0.841 |
| Thu 03/14/2013 | Bank of Oklahoma Center, Tulsa, OK
| 81 - 66 | 144 (13-17) UAB at 56 (25-10) Southern Miss | Home | W | 0.909 |
| Fri 03/15/2013 | Bank of Oklahoma Center, Tulsa, OK
| 85 - 67 | 58 (18-14) UTEP at 56 (25-10) Southern Miss | Home | W | 0.927 |
| Sat 03/16/2013 | Bank of Oklahoma Center, Tulsa, OK
| 91 - 79 | 56 (25-10) Southern Miss at 11 (31-5) Memphis | Away | L | 0.196 |
| Wed 03/20/2013 | Reed Green Coliseum, Hattiesburg, MS
| 78 - 71 | 200 (16-13) CSU at 56 (25-10) Southern Miss | Home | W | 0.937 |
| Mon 03/25/2013 | Reed Green Coliseum, Hattiesburg, MS
| 63 - 52 | 133 (26-7) Louisiana Tech at 56 (25-10) Southern Miss | Home | W | 0.918 |
| Wed 03/27/2013 | Reed Green Coliseum, Hattiesburg, MS
| 62 - 79 | 46 (23-12) BYU at 56 (25-10) Southern Miss | Home | L | 0.081 |