| Game Date | Arena | Score | Opponent | Location | Outcome | Game Chart |
| Sun 11/11/2012 | Taco Bell Arena, Boise, ID
| 81 - 63 | 162 (17-14) Texas Southern at 89 (19-11) Boise St | Away | L | 0.014 |
| Tue 11/13/2012 | Welsh-Ryan Arena, Evanston, IL
| 79 - 49 | 162 (17-14) Texas Southern at 104 (13-19) Northwestern | Away | L | 0.004 |
| Fri 11/16/2012 | Health & PE Center, Houston, TX
| 74 - 71 | 218 (12-20) LA-Lafayette at 162 (17-14) Texas Southern | Home | W | 0.742 |
| Sun 11/18/2012 | Jack Breslin Student Events Center, East Lansing, MI
| 69 - 41 | 162 (17-14) Texas Southern at 14 (26-9) Michigan St | Away | L | 0.002 |
| Tue 11/20/2012 | Health & PE Center, Houston, TX
| 69 - 71 | 176 (14-17) Oakland at 162 (17-14) Texas Southern | Home | L | 0.562 |
| Sat 11/24/2012 | Murphy Athletic Center, Murfreesboro, TN
| 79 - 52 | 162 (17-14) Texas Southern at 51 (28-6) Mid Tennessee | Away | L | 0.007 |
| Tue 11/27/2012 | Coors Events Center, Boulder, CO
| 85 - 80 | 162 (17-14) Texas Southern at 29 (21-12) Colorado | Away | L | 0.122 |
| Mon 12/03/2012 | Viejas Arena at Aztec Bowl, San Diego, CA
| 74 - 62 | 162 (17-14) Texas Southern at 54 (21-11) San Diego St | Away | L | 0.014 |
| Sat 12/08/2012 | Hofheinz Pavilion, Houston, TX
| 78 - 75 | 162 (17-14) Texas Southern at 211 (19-13) Houston | Away | L | 0.646 |
| Sun 12/16/2012 | Health & PE Center, Houston, TX
| 86 - 93 | 262 (12-18) CS Fullerton at 162 (17-14) Texas Southern | Home | L | 0.413 |
| Tue 12/18/2012 | Fred Bramlage Coliseum, Manhattan, KS
| 78 - 69 | 162 (17-14) Texas Southern at 31 (26-8) Kansas St | Away | L | 0.020 |
| Sat 12/22/2012 | Health & PE Center, Houston, TX
| 45 - 48 | 142 (18-14) Florida Int at 162 (17-14) Texas Southern | Home | L | 0.225 |
| Thu 12/27/2012 | James A. Rhodes H&PE Building, Akron, OH
| 83 - 68 | 162 (17-14) Texas Southern at 67 (25-7) Akron | Away | L | 0.004 |
| Wed 01/02/2013 | F.G. Clark Center, Baton Rouge, LA
| 63 - 57 | 162 (17-14) Texas Southern at 268 (20-10) Southern | Away | L | 0.573 |
| Fri 01/04/2013 | David L. Whitney Gymnasium, Lorman, MS
| 48 - 57 | 162 (17-14) Texas Southern at 290 (9-23) Alcorn St | Away | W | 0.793 |
| Sun 01/06/2013 | William Nicks Center, Prairie View, TX
| 60 - 65 | 162 (17-14) Texas Southern at 342 (12-19) Prairie View A&M | Away | W | 0.622 |
| Sat 01/12/2013 | Health & PE Center, Houston, TX
| 84 - 57 | 324 (11-18) Jackson St at 162 (17-14) Texas Southern | Home | W | 0.900 |
| Mon 01/14/2013 | Health & PE Center, Houston, TX
| 95 - 50 | 347 (0-28) Grambling St at 162 (17-14) Texas Southern | Home | W | 0.935 |
| Sat 01/19/2013 | H.O. Clemmons Arena, Pine Bluff, AR
| 66 - 63 | 162 (17-14) Texas Southern at 278 (16-14) AR-Pine Bluff | Away | L | 0.257 |
| Mon 01/21/2013 | Harrison Complex, Itta Bena, MS
| 48 - 75 | 162 (17-14) Texas Southern at 344 (5-23) Miss. Valley St | Away | W | 0.983 |
| Sat 01/26/2013 | Health & PE Center, Houston, TX
| 89 - 56 | 345 (9-20) Alabama A&M at 162 (17-14) Texas Southern | Home | W | 0.957 |
| Mon 01/28/2013 | Health & PE Center, Houston, TX
| 97 - 65 | 319 (9-22) Alabama St at 162 (17-14) Texas Southern | Home | W | 0.941 |
| Sat 02/02/2013 | Health & PE Center, Houston, TX
| 84 - 48 | 342 (12-19) Prairie View A&M at 162 (17-14) Texas Southern | Home | W | 0.923 |
| Sat 02/09/2013 | Williams Center, Jackson, MS
| 54 - 61 | 162 (17-14) Texas Southern at 324 (11-18) Jackson St | Away | W | 0.713 |
| Mon 02/11/2013 | Assembly Center, Grambling, LA
| 52 - 80 | 162 (17-14) Texas Southern at 347 (0-28) Grambling St | Away | W | 0.858 |
| Sat 02/16/2013 | Health & PE Center, Houston, TX
| 75 - 69 | 278 (16-14) AR-Pine Bluff at 162 (17-14) Texas Southern | Home | W | 0.839 |
| Mon 02/18/2013 | Health & PE Center, Houston, TX
| 73 - 57 | 344 (5-23) Miss. Valley St at 162 (17-14) Texas Southern | Home | W | 0.945 |
| Sat 02/23/2013 | Elmore Building, Normal, AL
| 62 - 64 | 162 (17-14) Texas Southern at 345 (9-20) Alabama A&M | Away | W | 0.645 |
| Mon 02/25/2013 | Dunn-Oliver Acadome, Montgomery, AL
| 50 - 70 | 162 (17-14) Texas Southern at 319 (9-22) Alabama St | Away | W | 0.806 |
| Thu 02/28/2013 | Health & PE Center, Houston, TX
| 79 - 66 | 268 (20-10) Southern at 162 (17-14) Texas Southern | Home | W | 0.929 |
| Sat 03/02/2013 | Health & PE Center, Houston, TX
| 78 - 59 | 290 (9-23) Alcorn St at 162 (17-14) Texas Southern | Home | W | 0.934 |