| Game Date | Arena | Score | Opponent | Location | Outcome | Game Chart |
| Sun 11/11/2012 | KFC Yum! Center, Louisville, KY
| 79 - 51 | 193 (14-18) Manhattan at 1 (35-5) Louisville | Home | W | 0.995 |
| Thu 11/15/2012 | KFC Yum! Center, Louisville, KY
| 80 - 54 | 233 (10-21) Samford at 1 (35-5) Louisville | Home | W | 0.999 |
| Sun 11/18/2012 | KFC Yum! Center, Louisville, KY
| 80 - 39 | 210 (8-22) Miami (OH) at 1 (35-5) Louisville | Home | W | 0.997 |
| Thu 11/22/2012 | Imperial Arena at Atlantis Resort, Nassau
| 51 - 46 | 74 (20-15) Northern Iowa at 1 (35-5) Louisville | Neutral | W | 0.923 |
| Fri 11/23/2012 | Imperial Arena at Atlantis Resort, Nassau
| 84 - 61 | 25 (23-11) Missouri at 1 (35-5) Louisville | Neutral | W | 0.898 |
| Sat 11/24/2012 | Imperial Arena at Atlantis Resort, Nassau
| 71 - 76 | 2 (30-6) Duke at 1 (35-5) Louisville | Neutral | L | 0.382 |
| Sat 12/01/2012 | KFC Yum! Center, Louisville, KY
| 69 - 66 | 99 (18-15) Illinois St at 1 (35-5) Louisville | Home | W | 0.607 |
| Tue 12/04/2012 | TD Bank Arena, Charleston, SC
| 38 - 80 | 1 (35-5) Louisville at 119 (24-10) Charleston | Away | W | 0.970 |
| Sat 12/08/2012 | KFC Yum! Center, Louisville, KY
| 99 - 47 | 242 (7-24) UMKC at 1 (35-5) Louisville | Home | W | 0.999 |
| Sat 12/15/2012 | FedExForum, Memphis, TN
| 78 - 87 | 1 (35-5) Louisville at 11 (31-5) Memphis | Away | W | 0.464 |
| Wed 12/19/2012 | KFC Yum! Center, Louisville, KY
| 79 - 55 | 142 (18-14) Florida Int at 1 (35-5) Louisville | Home | W | 0.977 |
| Sat 12/22/2012 |
| 55 - 78 | 1 (35-5) Louisville at 154 (19-16) W Kentucky | Neutral | W | 0.986 |
| Sat 12/29/2012 | KFC Yum! Center, Louisville, KY
| 80 - 77 | 50 (21-12) Kentucky at 1 (35-5) Louisville | Home | W | 0.830 |
| Wed 01/02/2013 | KFC Yum! Center, Louisville, KY
| 80 - 62 | 66 (19-15) Providence at 1 (35-5) Louisville | Home | W | 0.934 |
| Wed 01/09/2013 | Prudential Center, Newark, NJ
| 58 - 73 | 1 (35-5) Louisville at 101 (15-18) Seton Hall | Away | W | 0.830 |
| Sat 01/12/2013 | KFC Yum! Center, Louisville, KY
| 64 - 38 | 85 (12-19) South Florida at 1 (35-5) Louisville | Home | W | 0.994 |
| Mon 01/14/2013 | XL Center, Hartford, CT
| 58 - 73 | 1 (35-5) Louisville at 41 (20-10) Connecticut | Away | W | 0.638 |
| Sat 01/19/2013 | KFC Yum! Center, Louisville, KY
| 68 - 70 | 4 (30-10) Syracuse at 1 (35-5) Louisville | Home | L | 0.637 |
| Tue 01/22/2013 | The Pavilion, Villanova, PA
| 73 - 64 | 1 (35-5) Louisville at 49 (19-14) Villanova | Away | L | 0.392 |
| Sat 01/26/2013 | Verizon Center, Washington, DC
| 53 - 51 | 1 (35-5) Louisville at 15 (25-7) Georgetown | Away | L | 0.302 |
| Mon 01/28/2013 | KFC Yum! Center, Louisville, KY
| 64 - 61 | 45 (24-9) Pittsburgh at 1 (35-5) Louisville | Home | W | 0.867 |
| Sun 02/03/2013 | KFC Yum! Center, Louisville, KY
| 70 - 51 | 12 (26-9) Marquette at 1 (35-5) Louisville | Home | W | 0.910 |
| Wed 02/06/2013 | Louis Brown Athletic Center, Piscataway, NJ
| 48 - 68 | 1 (35-5) Louisville at 70 (15-16) Rutgers | Away | W | 0.981 |
| Sat 02/09/2013 | Purcell Pavilion at the Joyce Center, South Bend, IN
| 104 - 101 | 1 (35-5) Louisville at 33 (25-10) Notre Dame | Away | L | 0.605 |
| Thu 02/14/2013 | KFC Yum! Center, Louisville, KY
| 72 - 58 | 57 (17-16) St. Johns at 1 (35-5) Louisville | Home | W | 0.926 |
| Sun 02/17/2013 | USF Sun Dome, Tampa, FL
| 41 - 59 | 1 (35-5) Louisville at 85 (12-19) South Florida | Away | W | 0.916 |
| Sat 02/23/2013 | KFC Yum! Center, Louisville, KY
| 79 - 61 | 101 (15-18) Seton Hall at 1 (35-5) Louisville | Home | W | 0.970 |
| Wed 02/27/2013 | Allstate Arena, Rosemont, IL
| 58 - 79 | 1 (35-5) Louisville at 143 (11-21) DePaul | Away | W | 0.897 |
| Sat 03/02/2013 | Carrier Dome, Syracuse, NY
| 53 - 58 | 1 (35-5) Louisville at 4 (30-10) Syracuse | Away | W | 0.524 |
| Mon 03/04/2013 | KFC Yum! Center, Louisville, KY
| 67 - 51 | 26 (22-12) Cincinnati at 1 (35-5) Louisville | Home | W | 0.842 |
| Sat 03/09/2013 | KFC Yum! Center, Louisville, KY
| 73 - 57 | 33 (25-10) Notre Dame at 1 (35-5) Louisville | Home | W | 0.883 |
| Thu 03/14/2013 | Madison Square Garden, New York, NY
| 74 - 55 | 49 (19-14) Villanova at 1 (35-5) Louisville | Home | W | 0.919 |
| Fri 03/15/2013 | Madison Square Garden, New York, NY
| 69 - 57 | 33 (25-10) Notre Dame at 1 (35-5) Louisville | Home | W | 0.811 |
| Sat 03/16/2013 | Madison Square Garden, New York, NY
| 78 - 61 | 4 (30-10) Syracuse at 1 (35-5) Louisville | Home | W | 0.598 |
| Thu 03/21/2013 | Rupp Arena, Lexington, KY
| 79 - 48 | 204 (19-17) N Carolina A&T at 1 (35-5) Louisville | Home | W | 0.999 |
| Sat 03/23/2013 | Rupp Arena, Lexington, KY
| 82 - 56 | 47 (24-9) Colorado St at 1 (35-5) Louisville | Home | W | 0.927 |
| Fri 03/29/2013 | Lucas Oil Stadium, Indianapolis, IN
| 77 - 69 | 37 (28-9) Oregon at 1 (35-5) Louisville | Home | W | 0.924 |
| Sun 03/31/2013 | Lucas Oil Stadium, Indianapolis, IN
| 85 - 63 | 2 (30-6) Duke at 1 (35-5) Louisville | Home | W | 0.833 |
| Sat 04/06/2013 | Georgia Dome, Atlanta, GA
| 72 - 68 | 28 (30-9) Wichita St at 1 (35-5) Louisville | Home | W | 0.502 |
| Mon 04/08/2013 | Georgia Dome, Atlanta, GA
| 82 - 76 | 18 (30-8) Michigan at 1 (35-5) Louisville | Home | W | 0.650 |